Recombinant Human Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 57.8kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM)

Recombinant Human Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM) — Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Purity >85%.

SKU: BCRECP-001250 Categories: ,
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Product Specifications

Product SkuBCRECP-001250
Product DescriptionRecombinant Human Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 20-496aa. [Accession | Q6P988].
Uniprot No.Q6P988
Gene NamesNOTUM
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region20-496aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight57.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Rarely expressed in adult normal tissues

Product Specifications

Recombinant Human Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 20-496aa, with N-terminal 6xHis-tagged tag, molecular weight 57.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175)

Subcellular Location

Secreted

Tissue Specificity

Rarely expressed in adult normal tissues

Gene: NOTUM  |  Organism: Homo sapiens  |  Synonyms: hNOTUM
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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