Recombinant Human PITH domain-containing protein 1 (PITHD1), Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 31.6kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human PITH domain-containing protein 1 (PITHD1)

Recombinant Human PITH domain-containing protein 1 (PITHD1) — Promotes megakaryocyte differentiation by up-regulating RUNX1 expression. Purity >90%.

SKU: BCRECP-001386 Category:
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Product Specifications

Product SkuBCRECP-001386
Product DescriptionRecombinant Human PITH domain-containing protein 1 (PITHD1) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1-211aa. [Accession | Q9GZP4].
Uniprot No.Q9GZP4
Gene NamesPITHD1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-211aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight31.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Promotes megakaryocyte differentiation by up-regulating RUNX1 expression. Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Down-regulated in primary acute myeloid leukemia (AML) patients

Product Specifications

Recombinant Human PITH domain-containing protein 1 (PITHD1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-211aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 31.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Promotes megakaryocyte differentiation by up-regulating RUNX1 expression (PubMed:25134913). Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene (PubMed:25134913)

Subcellular Location

Cytoplasm

Tissue Specificity

Down-regulated in primary acute myeloid leukemia (AML) patients

Gene: PITHD1  |  Organism: Homo sapiens
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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