Recombinant Human Plasminogen protein (PLG), partial (Active), Homo sapiens (Human), E.Coli, Tag-Free, 29.7 kDa, purity >>95% as determined by SDS-PAGE.

Recombinant Human Plasminogen protein (PLG), partial (Active)

Recombinant Human Plasminogen protein (PLG), partial (Active) — (Microbial infection) Interacts with dengue virus type 2 particles. Purity >95%.

SKU: BCACP-000883 Category:
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Product SKUBCACP-000883
Product DescriptionRecombinant Human Plasminogen protein (PLG) protein is expressed from E.Coli with Tag-Free. It contains 98-356aa. [Accession | P00747].
Uniprot No.P00747
Gene NamesPLG
Purity>95% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region98-356aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight29.7 kDa
ActivityFully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 0.1-10 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesPlasmin; Plasmin heavy chain A; Plasmin light chain B; Plasminogen; PLG; PLMN_HUMAN

Function

(Microbial infection) Interacts with dengue virus type 2 particles. Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Present in plasma and many other extracellular fluids. It is synthesized in the liver
Disease Association: Plasminogen deficiency (PLGD) : A disorder characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa. [The disease is caused by variants affecting the gene represented in this entry] | Angioedema, hereditary, 4 (HAE4) : A form of angioedema, a disorder characterized by episodic local swelling involving subcutaneous or submucous tissue of the upper respiratory and gastrointestinal tracts, face, extremities, and genitalia. HAE4 is an autosomal dominant form with incomplete penetrance, variable expressivity, and female predominance. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Plasminogen protein (PLG), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in E.Coli, covering amino acids 98-356aa, with Tag-Free tag, molecular weight 29.7 kDa, purity >95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 0.1-10 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

(Microbial infection) Interacts with dengue virus type 2 particles (PubMed:31726374). Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes (PubMed:31726374)

Subcellular Location

Secreted

Disease Association

Plasminogen deficiency (PLGD) : A disorder characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa. [The disease is caused by variants affecting the gene represented in this entry] | Angioedema, hereditary, 4 (HAE4) : A form of angioedema, a disorder characterized by episodic local swelling involving subcutaneous or submucous tissue of the upper respiratory and gastrointestinal tracts, face, extremities, and genitalia. HAE4 is an autosomal dominant form with incomplete penetrance, variable expressivity, and female predominance. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Present in plasma and many other extracellular fluids. It is synthesized in the liver

Subunit

(Microbial infection) Interacts with B.burgdorferi OspC

Gene: PLG  |  Organism: Homo sapiens
Key Publications

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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