Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP11), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 41.0kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP11), partial

Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP11), partial — Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Purity >90%.

SKU: BCRECP-001332 Category:
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Product Specifications

Product SkuBCRECP-001332
Product DescriptionRecombinant Human Poly [ADP-ribose] polymerase 1 (PARP11) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 9-338aa. [Accession | Q9NR21].
Uniprot No.Q9NR21
Gene NamesPARP11
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region9-338aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight41.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis. Inhibits the type I interferon activated signaling pathway.

Biological Context

Subcellular Location: Nucleus, nuclear pore complex

Product Specifications

Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP11), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 9-338aa, with N-terminal 6xHis-tagged tag, molecular weight 41.0kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). Inhibits the type I interferon activated signaling pathway (PubMed:30988430). Mechanistically, mono-ADP-ribosylates beta-TrCP/BTRC to promote IFNAR1 ubiquitination and protect BTRC from ubiquitin-proteasome degradation. Additionally, acts as an antiviral factor by cooperating with PARP12 to suppress Zika virus replication, independent of IFNAR1 regulation or intrinsic PARP enzymatic activity (PubMed:34187568). Instead, facilitates the degradation of viral NS1 and NS3 proteins, potentially disrupting viral replication (PubMed:34187568)

Subcellular Location

Nucleus, nuclear pore complex

Subunit

Interacts with PARP12; this interaction plays a role in zika virus suppression

Gene: PARP11  |  Organism: Homo sapiens  |  Synonyms: ADP-ribosyltransferase diphtheria toxin-like 11; Poly [ADP-ribose] polymerase 11

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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