Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP11), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 41.0kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP11), partial

Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP11), partial — Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Purity >90%.

SKU: BCRECP-001332 Category:
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Product Specifications

Product SkuBCRECP-001332
Product DescriptionRecombinant Human Poly [ADP-ribose] polymerase 1 (PARP11) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 9-338aa. [Accession | Q9NR21].
Uniprot No.Q9NR21
Gene NamesPARP11
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region9-338aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight41.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis. Inhibits the type I interferon activated signaling pathway.

Biological Context

Subcellular Location: Nucleus, nuclear pore complex

Product Specifications

Recombinant Human Poly [ADP-ribose] polymerase 1 (PARP11), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 9-338aa, with N-terminal 6xHis-tagged tag, molecular weight 41.0kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). Inhibits the type I interferon activated signaling pathway (PubMed:30988430). Mechanistically, mono-ADP-ribosylates beta-TrCP/BTRC to promote IFNAR1 ubiquitination and protect BTRC from ubiquitin-proteasome degradation. Additionally, acts as an antiviral factor by cooperating with PARP12 to suppress Zika virus replication, independent of IFNAR1 regulation or intrinsic PARP enzymatic activity (PubMed:34187568). Instead, facilitates the degradation of viral NS1 and NS3 proteins, potentially disrupting viral replication (PubMed:34187568)

Subcellular Location

Nucleus, nuclear pore complex

Subunit

Interacts with PARP12; this interaction plays a role in zika virus suppression

Gene: PARP11  |  Organism: Homo sapiens  |  Synonyms: ADP-ribosyltransferase diphtheria toxin-like 11; Poly [ADP-ribose] polymerase 11

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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