Recombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2), Homo sapiens (Human), Yeast, C-terminal 6xHis-tagged, 16.8kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2)

Recombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2) — Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Purity >95%.

SKU: BCRECP-001325 Category:
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Product Specifications

Product SkuBCRECP-001325
Product DescriptionRecombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2) Protein is expressed from Yeast with C-terminal 6xHis-tagged. It contains 1-127aa. [Accession | Q9BPZ3].
Uniprot No.Q9BPZ3
Gene NamesPAIP2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-127aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight16.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid

Product Specifications

Recombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-127aa, with C-terminal 6xHis-tagged tag, molecular weight 16.8kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization

Subcellular Location

Cytoplasm

Tissue Specificity

Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid

Subunit

Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1 stoichiometry

Gene: PAIP2  |  Organism: Homo sapiens
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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