Recombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2), Homo sapiens (Human), Yeast, C-terminal 6xHis-tagged, 16.8kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2)

Recombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2) — Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Purity >95%.

SKU: BCRECP-001325 Category:
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Product Specifications

Product SkuBCRECP-001325
Product DescriptionRecombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2) Protein is expressed from Yeast with C-terminal 6xHis-tagged. It contains 1-127aa. [Accession | Q9BPZ3].
Uniprot No.Q9BPZ3
Gene NamesPAIP2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-127aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight16.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid

Product Specifications

Recombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-127aa, with C-terminal 6xHis-tagged tag, molecular weight 16.8kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization

Subcellular Location

Cytoplasm

Tissue Specificity

Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid

Subunit

Interacts with the second and third RRM domains and C-terminus regions of PABPC1 in a 2:1 stoichiometry

Gene: PAIP2  |  Organism: Homo sapiens
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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