Recombinant Human Potassium channel subfamily K member 13 (KCNK13) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 51.4kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Potassium channel subfamily K member 13 (KCNK13) Protein

Recombinant Human Potassium channel subfamily K member 13 (KCNK13) Protein — K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals. Purity >85%.

SKU: BCRECP-00020TM Category:
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Product Specifications

Uniprot No.Q9HB14
Gene NamesKCNK13
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-408aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight51.4kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. Contributes most of K(+) currents at the plasma membrane of resting microglia.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Expressed in microglia (at protein level)

Product Specifications

Recombinant Human Potassium channel subfamily K member 13 (KCNK13) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-408aa, with N-terminal 10xHis-tagged tag, molecular weight 51.4kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals (PubMed:24163367, PubMed:25148687, PubMed:30472253, PubMed:38409076). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:25148687, PubMed:40011745, PubMed:40011746, PubMed:40307591, PubMed:40178898). Contributes most of K(+) currents at the plasma membrane of resting microglia (PubMed:38409076). Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses (PubMed:38409076). Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (PubMed:38409076)

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Tissue Specificity

Expressed in microglia (at protein level)

Subunit

Homodimer (PubMed:40011745, PubMed:40011746, PubMed:40178898, PubMed:40307591). Heterodimer with KCNK12 (PubMed:25148687)

Gene: KCNK13  |  Organism: Homo sapiens  |  Synonyms: Tandem pore domain halothane-inhibited potassium channel 1
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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