Recombinant Human Pregnancy zone protein (PZP), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 42.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Pregnancy zone protein (PZP), partial

Recombinant Human Pregnancy zone protein (PZP), partial — Is able to inhibit all four classes of proteinases by a unique ‘trapping’ mechanism. Purity >90%.

SKU: BCRECP-001496 Category:
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Product Specifications

Product SkuBCRECP-001496
Product DescriptionRecombinant Human Pregnancy zone protein (PZP) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 472-821aa. [Accession | P20742].
Uniprot No.P20742
Gene NamesPZP
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region472-821aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight42.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Plasma. Prominent constituent of late-pregnancy sera

Product Specifications

Recombinant Human Pregnancy zone protein (PZP), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 472-821aa, with N-terminal 6xHis-tagged tag, molecular weight 42.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase

Subcellular Location

Secreted

Tissue Specificity

Plasma. Prominent constituent of late-pregnancy sera

Subunit

Homotetramer, which consists of two pairs of disulfide-linked chains

Gene: PZP  |  Organism: Homo sapiens  |  Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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