Recombinant Human Pregnancy zone protein (PZP), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 42.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Pregnancy zone protein (PZP), partial

Recombinant Human Pregnancy zone protein (PZP), partial — Is able to inhibit all four classes of proteinases by a unique ‘trapping’ mechanism. Purity >90%.

SKU: BCRECP-001496 Category:
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Product Specifications

Product SkuBCRECP-001496
Product DescriptionRecombinant Human Pregnancy zone protein (PZP) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 472-821aa. [Accession | P20742].
Uniprot No.P20742
Gene NamesPZP
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region472-821aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight42.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Plasma. Prominent constituent of late-pregnancy sera

Product Specifications

Recombinant Human Pregnancy zone protein (PZP), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 472-821aa, with N-terminal 6xHis-tagged tag, molecular weight 42.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase

Subcellular Location

Secreted

Tissue Specificity

Plasma. Prominent constituent of late-pregnancy sera

Subunit

Homotetramer, which consists of two pairs of disulfide-linked chains

Gene: PZP  |  Organism: Homo sapiens  |  Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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