Recombinant Human Probable ATP-dependent RNA helicase DDX60 (DDX60), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 23.1kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Probable ATP-dependent RNA helicase DDX60 (DDX60), partial

Recombinant Human Probable ATP-dependent RNA helicase DDX60 (DDX60), partial — Positively regulates RIGI- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Purity >85%.

SKU: BCRECP-000494 Category:
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Product Specifications

Product SkuBCRECP-000494
Product DescriptionRecombinant Human Probable ATP-dependent RNA helicase DDX60 (DDX60) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 772-939aa. [Accession | Q8IY21].
Uniprot No.Q8IY21
Gene NamesDDX60
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region772-939aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight23.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Positively regulates RIGI- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of RIGI to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Brain, lymph node, prostate, stomach, thyroid, tongue, trachea, uterus, skeletal muscle, spleen, kidney, liver and small intestine

Product Specifications

Recombinant Human Probable ATP-dependent RNA helicase DDX60 (DDX60), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 772-939aa, with N-terminal 6xHis-tagged tag, molecular weight 23.1kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Positively regulates RIGI- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of RIGI to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). Selectively reduces infectious titers of viruses that depend on type II IRES-mediated translation by modulating ribosome occupancy on type II IRES-containing viral mRNAs, without affecting type I IRES-mediated translation (PubMed:36256515)

Subcellular Location

Cytoplasm

Tissue Specificity

Brain, lymph node, prostate, stomach, thyroid, tongue, trachea, uterus, skeletal muscle, spleen, kidney, liver and small intestine

Subunit

Interacts with EXOSC1, EXOSC4, RIGI, IFIH1/MDA5 and DHX58/LGP2

Gene: DDX60  |  Organism: Homo sapiens  |  Synonyms: DEAD box protein 60

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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