Recombinant Human Programmed cell death protein 5 (PDCD5), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 41.2kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Programmed cell death protein 5 (PDCD5)

Recombinant Human Programmed cell death protein 5 (PDCD5) — In response to DNA damage, associates with TP53/p53 to prevent MDM2-mediated degradation of TP53 and promote TP53-mediated signaling. Purity >90%.

SKU: BCRECP-001361 Category:
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Product Specifications

Product SkuBCRECP-001361
Product DescriptionRecombinant Human Programmed cell death protein 5 (PDCD5) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-125aa. [Accession | O14737].
Uniprot No.O14737
Gene NamesPDCD5
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-125aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight41.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

In response to DNA damage, associates with TP53/p53 to prevent MDM2-mediated degradation of TP53 and promote TP53-mediated signaling. Also protects KAT5/TIP60 from degradation, which further promotes TP53/p53-mediated signaling.

Biological Context

Subcellular Location: Nucleus; Cytoplasm, cytosol
Tissue Specificity: Widely expressed. Highest levels in heart, testis, kidney, pituitary gland, adrenal gland and placenta

Product Specifications

Recombinant Human Programmed cell death protein 5 (PDCD5) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-125aa, with N-terminal GST-tagged tag, molecular weight 41.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

In response to DNA damage, associates with TP53/p53 to prevent MDM2-mediated degradation of TP53 and promote TP53-mediated signaling (PubMed:19616514, PubMed:22914926, PubMed:28051100). Also protects KAT5/TIP60 from degradation, which further promotes TP53/p53-mediated signaling (PubMed:19308289)

Subcellular Location

Nucleus; Cytoplasm, cytosol

Tissue Specificity

Widely expressed. Highest levels in heart, testis, kidney, pituitary gland, adrenal gland and placenta

Subunit

Interacts (via N-terminus) with PPEF1; the interaction is direct, and leads to dephosphorylation of PDCD5 at Ser-119, PDCD5 destabilization, and downstream inhibition of TP53/p53-mediated signaling (PubMed:28051100). Interacts with TP53; the interaction is direct and prevents the interaction between TP53 and MDM2, thereby stabilizing TP53 (PubMed:22914926). Interacts with KAT5/TIP60; the interaction is direct and leads to stabilization of the KAT5 protein (PubMed:19308289)

Gene: PDCD5  |  Organism: Homo sapiens  |  Synonyms: TF-1 cell apoptosis-related protein 19
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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