Recombinant Human Protein DEK (DEK) (S375SLEH), partial, Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 15.7kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Protein DEK (DEK) (S375SLEH), partial

Recombinant Human Protein DEK (DEK) (S375SLEH), partial — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-000499 Category:
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Product Specifications

Product SkuBCRECP-000499
Product DescriptionRecombinant Human Protein DEK (DEK) (S375SLEH) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 309-375aa(S375SLEH). [Accession | P35659].
Uniprot No.P35659
Gene NamesDEK
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region309-375aa(S375SLEH)
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight15.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Involved in chromatin organization.

Biological Context

Subcellular Location: Nucleus
Tissue Specificity: Ubiquitous. Expressed at relatively high levels
Disease Association: [A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-NUP214 fusion gene ]

Product Specifications

Recombinant Human Protein DEK (DEK) (S375SLEH), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 309-375aa(S375SLEH), with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 15.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Involved in chromatin organization

Subcellular Location

Nucleus

Disease Association

[A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122)]

Tissue Specificity

Ubiquitous. Expressed at relatively high levels

Subunit

Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA

Gene: DEK  |  Organism: Homo sapiens
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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