Recombinant Human Proteoglycan 4 (PRG4), partial, Homo sapiens (Human), Baculovirus, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 18.6kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Proteoglycan 4 (PRG4), partial

Recombinant Human Proteoglycan 4 (PRG4), partial — recombinant protein from Homo sapiens (Human), expressed in Baculovirus. Purity >85%.

SKU: BCRECP-001443 Category:
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Product Specifications

Product SkuBCRECP-001443
Product DescriptionRecombinant Human Proteoglycan 4 (PRG4) Protein is expressed from Baculovirus with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 25-156aa. [Accession | Q92954].
Uniprot No.Q92954
Gene NamesPRG4
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemBaculovirus
Expression Region25-156aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight18.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed
Disease Association: Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) : An autosomal recessive disorder characterized by the association of congenital or early-onset camptodactyly and non-inflammatory arthropathy with synovial hyperplasia. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure, non-inflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. Some patients also manifest progressive coxa vara deformity and/or non-inflammatory pericardial or pleural effusions. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Proteoglycan 4 (PRG4), partial is a recombinant protein from Homo sapiens (Human), expressed in Baculovirus, covering amino acids 25-156aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 18.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages

Subcellular Location

Secreted

Disease Association

Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) : An autosomal recessive disorder characterized by the association of congenital or early-onset camptodactyly and non-inflammatory arthropathy with synovial hyperplasia. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure, non-inflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. Some patients also manifest progressive coxa vara deformity and/or non-inflammatory pericardial or pleural effusions. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed

Subunit

Homodimer; disulfide-linked

Gene: PRG4  |  Organism: Homo sapiens  |  Synonyms: Lubricin; Megakaryocyte-stimulating factor; Superficial zone proteoglycan
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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