Recombinant Human Pyridoxal kinase (PDXK), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 62.1kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Pyridoxal kinase (PDXK)

Recombinant Human Pyridoxal kinase (PDXK) — Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5′-phosphate (PLP), pyridoxine 5′-phosphate (PNP) and pyrido… Purity >90%.

SKU: BCRECP-001366 Categories: , ,
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Product Specifications

Product SkuBCRECP-001366
Product DescriptionRecombinant Human Pyridoxal kinase (PDXK) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-312aa. [Accession | O00764].
Uniprot No.O00764
Gene NamesPDXK
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-312aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight62.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.

Biological Context

Subcellular Location: Cytoplasm, cytosol
Tissue Specificity: In adult testis and spermatozoa
Disease Association: Neuropathy, hereditary motor and sensory, 6C, with optic atrophy (HMSN6C) : An autosomal recessive neurologic disorder characterized by childhood onset of axonal, sensorimotor polyneuropathy affecting mainly the lower limbs, and adult-onset optic atrophy. Clinical features include progressive distal muscle weakness and atrophy, significant standing and walking difficulties, areflexia, neurogenic pain and progressive visual impairment. [The disease is caused by variants affecting the gene represented in this entry]
Pathway: Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1

Product Specifications

Recombinant Human Pyridoxal kinase (PDXK) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-312aa, with N-terminal GST-tagged tag, molecular weight 62.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable) (PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503, PubMed:9099727). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions

Subcellular Location

Cytoplasm, cytosol

Disease Association

Neuropathy, hereditary motor and sensory, 6C, with optic atrophy (HMSN6C) : An autosomal recessive neurologic disorder characterized by childhood onset of axonal, sensorimotor polyneuropathy affecting mainly the lower limbs, and adult-onset optic atrophy. Clinical features include progressive distal muscle weakness and atrophy, significant standing and walking difficulties, areflexia, neurogenic pain and progressive visual impairment. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

In adult testis and spermatozoa

Subunit

Homodimer

Pathway

Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1

Gene: PDXK  |  Organism: Homo sapiens  |  Synonyms: Pyridoxine kinase
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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