Recombinant Human Ras-related protein Rab-6A (RAB6A), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 24.4kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Ras-related protein Rab-6A (RAB6A)

Recombinant Human Ras-related protein Rab-6A (RAB6A) — The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Purity >95%.

SKU: BCRECP-001507 Category:
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Product Specifications

Product SkuBCRECP-001507
Product DescriptionRecombinant Human Ras-related protein Rab-6A (RAB6A) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 2-208aa. [Accession | P20340].
Uniprot No.P20340
Gene NamesRAB6A
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region2-208aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight24.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasTransport

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER).

Biological Context

Subcellular Location: Golgi apparatus membrane (Lipid-anchor)
Tissue Specificity: Ubiquitous

Product Specifications

Recombinant Human Ras-related protein Rab-6A (RAB6A) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 2-208aa, with N-terminal 6xHis-tagged tag, molecular weight 24.4kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:25962623). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:25962623). RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623). Has a low GTPase activity (PubMed:25962623). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Plays a role in neuron projection development (Probable)

Subcellular Location

Golgi apparatus membrane (Lipid-anchor)

Tissue Specificity

Ubiquitous

Subunit

(Microbial infection) Interacts with human cytomegalovirus protein UL32

Gene: RAB6A  |  Organism: Homo sapiens
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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