Recombinant Human Ras-related protein Rab-6B (RAB6B), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 27.4kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Ras-related protein Rab-6B (RAB6B)

Recombinant Human Ras-related protein Rab-6B (RAB6B) — The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Purity >95%.

SKU: BCRECP-001509 Category:
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Product Specifications

Product SkuBCRECP-001509
Product DescriptionRecombinant Human Ras-related protein Rab-6B (RAB6B) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 2-208aa. [Accession | Q9NRW1].
Uniprot No.Q9NRW1
Gene NamesRAB6B
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-208aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight27.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology.

Biological Context

Subcellular Location: Golgi apparatus membrane (Lipid-anchor); Endoplasmic reticulum-Golgi intermediate compartment; Cytoplasmic vesicle
Tissue Specificity: Predominantly expressed in brain

Product Specifications

Recombinant Human Ras-related protein Rab-6B (RAB6B) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-208aa, with N-terminal 6xHis-tagged tag, molecular weight 27.4kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (By similarity). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866)

Subcellular Location

Golgi apparatus membrane (Lipid-anchor); Endoplasmic reticulum-Golgi intermediate compartment; Cytoplasmic vesicle

Tissue Specificity

Predominantly expressed in brain

Subunit

Interacts (GTP-bound) with BICD1 (via C-terminus); the interaction is direct (PubMed:17707369). Interacts (GDP-bound) with DYNLRB1 (PubMed:18044744). Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1 (PubMed:23737971). Interacts (GTP-bound) with VPS13B isoform 2 (PubMed:25492866)

Gene: RAB6B  |  Organism: Homo sapiens
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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