Recombinant Human Receptor-type tyrosine-protein phosphatase zeta (PTPRZ1), partial

Function

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity)

Subcellular Location

Secreted

Tissue Specificity

Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain

Subunit

The carbonic-anhydrase like domain interacts with CNTN1 (contactin) (PubMed:20133774). Interacts with PTN (PubMed:16814777). Interaction with PTN promotes formation of homooligomers; oligomerization impairs phosphatase activity (By similarity). Interacts (via chondroitin sulfate chains) with MDK (via C-terminal); this interaction is inhibited by PTN; this interaction promotes neuronal migration (By similarity)

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• Levy J.B. et al. The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. — J. Biol. Chem. (1993)
• Hillier L.W. et al. The DNA sequence of human chromosome 7. — Nature (2003)
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• Mural R.J. et al. PubMed: CI-5GBDQ6B103N1E (JUL-)
• Onyango P. et al. Molecular cloning and expression analysis of five novel genes in chromosome 1p36. — Genomics (1998)
• Krueger N.X. et al. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. — EMBO J. (1990)
• Kaplan R. et al. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. — Proc. Natl. Acad. Sci. U.S.A. (1990)