Recombinant Human Recoverin (RCVRN), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 27.0kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Recoverin (RCVRN)

Recombinant Human Recoverin (RCVRN) — Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells. Purity >90%.

SKU: BCRECP-001526 Category:
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Product Specifications

Product SkuBCRECP-001526
Product DescriptionRecombinant Human Recoverin (RCVRN) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 2-200aa. [Accession | P35243].
Uniprot No.P35243
Gene NamesRCVRN
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-200aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight27.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells. Modulates light sensitivity of cone photoreceptor in dark and dim conditions. In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin.

Biological Context

Subcellular Location: Photoreceptor inner segment; Cell projection, cilium, photoreceptor outer segment; Photoreceptor outer segment membrane (Lipid-anchor); Perikaryon
Tissue Specificity: Retina and pineal gland

Product Specifications

Recombinant Human Recoverin (RCVRN) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-200aa, with N-terminal 6xHis-tagged tag, molecular weight 27.0kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity)

Subcellular Location

Photoreceptor inner segment; Cell projection, cilium, photoreceptor outer segment; Photoreceptor outer segment membrane (Lipid-anchor); Perikaryon

Tissue Specificity

Retina and pineal gland

Subunit

Homodimer; disulfide-linked (By similarity). Homodimerization is caused by prolonged intense illumination (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity). Interacts (via C-terminus) with GRK1 (via N-terminus); the interaction is Ca(2+)-dependent (By similarity)

Gene: RCVRN  |  Organism: Homo sapiens  |  Synonyms: Cancer-associated retinopathy protein
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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