Function
Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
Biological Context
Subcellular Location: Secreted, extracellular space, extracellular matrix
Tissue Specificity: Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% in patients with schizophrenia. Also expressed in fetal and adult liver
Disease Association: Lissencephaly 2 (LIS2) : A classic type lissencephaly associated with ataxia, intellectual disability, seizures and abnormalities of the cerebellum, hippocampus and brainstem. [The disease is caused by variants affecting the gene represented in this entry] | Epilepsy, familial temporal lobe, 7 (ETL7) : A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Reelin (RELN), partial is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 26-254aa, with N-terminal 6xHis-tagged tag, molecular weight 26.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
