Recombinant Human Retinal dehydrogenase 2 (ALDH1A2), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 58.7kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Retinal dehydrogenase 2 (ALDH1A2)

Recombinant Human Retinal dehydrogenase 2 (ALDH1A2) — Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-tran… Purity >90%.

SKU: BCRECP-000056 Categories: ,
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Product Specifications

Product SkuBCRECP-000056
Product DescriptionRecombinant Human Retinal dehydrogenase 2 (ALDH1A2) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 1-518aa. [Accession | O94788].
Uniprot No.O94788
Gene NamesALDH1A2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-518aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight58.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively. Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein.

Biological Context

Subcellular Location: Cytoplasm
Disease Association: Diaphragmatic hernia 4, with cardiovascular defects (DIH4) : An autosomal recessive form of congenital diaphragmatic hernia, a posterolateral defect of the diaphragm, generally located on the left side, that permits the herniation of abdominal viscera into the thorax. The lungs are hypoplastic and have abnormal vessels that cause respiratory insufficiency and persistent pulmonary hypertension with high mortality. About one third of cases have cardiovascular malformations and lesser proportions have skeletal, neural, genitourinary, gastrointestinal or other defects. [The disease is caused by variants affecting the gene represented in this entry]
Pathway: Cofactor metabolism; retinol metabolism

Product Specifications

Recombinant Human Retinal dehydrogenase 2 (ALDH1A2) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-518aa, with N-terminal 6xHis-tagged tag, molecular weight 58.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:29240402, PubMed:33565183). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable) (PubMed:33565183). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal (By similarity). Displays complete lack of activity with citral (By similarity)

Subcellular Location

Cytoplasm

Disease Association

Diaphragmatic hernia 4, with cardiovascular defects (DIH4) : An autosomal recessive form of congenital diaphragmatic hernia, a posterolateral defect of the diaphragm, generally located on the left side, that permits the herniation of abdominal viscera into the thorax. The lungs are hypoplastic and have abnormal vessels that cause respiratory insufficiency and persistent pulmonary hypertension with high mortality. About one third of cases have cardiovascular malformations and lesser proportions have skeletal, neural, genitourinary, gastrointestinal or other defects. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Homotetramer

Pathway

Cofactor metabolism; retinol metabolism

Gene: ALDH1A2  |  Organism: Homo sapiens  |  Synonyms: Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase type 2
Key Publications

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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