Recombinant Human Retroviral-like aspartic protease 1 (ASPRV1) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 19.9kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Retroviral-like aspartic protease 1 (ASPRV1) Protein

Recombinant Human Retroviral-like aspartic protease 1 (ASPRV1) Protein — recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system. Purity >85%.

SKU: BCRECP-00601TM Categories: , ,
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Product Specifications

Uniprot No.Q53RT3
Gene NamesASPRV1
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region191-326aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight19.9kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization.

Biological Context

Subcellular Location: Membrane (Single-pass membrane protein)
Tissue Specificity: Expressed primarily in the granular layer of the epidermis and inner root sheath of hair follicles. In psoriatic skin, expressed throughout the stratum corneum. In ulcerated skin, expressed in the stratum granulosum of intact epidermis but almost absent from ulcerated regions. Expressed in differentiated areas of squamous cell carcinomas but not in undifferentiated tumors
Disease Association: Ichthyosis, lamellar, autosomal dominant (ADLI) : An autosomal dominant form of ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling. ADLI is characterized by onset at birth or within the first months of life, skin scaling on the entire body with relative sparing of face, anterior chest, and abdomen, and palmoplantar keratoderma. Patients may manifest mild erythema and moderate pruritus. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Retroviral-like aspartic protease 1 (ASPRV1) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 191-326aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 19.9kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization

Subcellular Location

Membrane (Single-pass membrane protein)

Disease Association

Ichthyosis, lamellar, autosomal dominant (ADLI) : An autosomal dominant form of ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling. ADLI is characterized by onset at birth or within the first months of life, skin scaling on the entire body with relative sparing of face, anterior chest, and abdomen, and palmoplantar keratoderma. Patients may manifest mild erythema and moderate pruritus. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed primarily in the granular layer of the epidermis and inner root sheath of hair follicles. In psoriatic skin, expressed throughout the stratum corneum. In ulcerated skin, expressed in the stratum granulosum of intact epidermis but almost absent from ulcerated regions. Expressed in differentiated areas of squamous cell carcinomas but not in undifferentiated tumors

Subunit

Homodimer

Gene: ASPRV1  |  Organism: Homo sapiens  |  Synonyms: Skin-specific retroviral-like aspartic protease; TPA-inducible aspartic proteinase-like protein
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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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