Recombinant Human Ribonucleoside-diphosphate reductase large subunit (RRM1), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 92.1kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Ribonucleoside-diphosphate reductase large subunit (RRM1)

Recombinant Human Ribonucleoside-diphosphate reductase large subunit (RRM1) — Provides the precursors necessary for DNA synthesis. Purity >90%.

SKU: BCRECP-001567 Categories: ,
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Product Specifications

Product SkuBCRECP-001567
Product DescriptionRecombinant Human Ribonucleoside-diphosphate reductase large subunit (RRM1) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 1-792aa. [Accession | P23921].
Uniprot No.P23921
Gene NamesRRM1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-792aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight92.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Biological Context

Subcellular Location: Cytoplasm
Disease Association: Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 6 (PEOB6) : A form of progressive external ophthalmoplegia, a mitochondrial myopathy characterized by progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged red fibers are seen on muscle biopsy. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Ribonucleoside-diphosphate reductase large subunit (RRM1) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-792aa, with N-terminal 6xHis-tagged tag, molecular weight 92.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

Subcellular Location

Cytoplasm

Disease Association

Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 6 (PEOB6) : A form of progressive external ophthalmoplegia, a mitochondrial myopathy characterized by progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged red fibers are seen on muscle biopsy. [The disease may be caused by variants affecting the gene represented in this entry]

Subunit

Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B. Interacts with AHCYL1 which inhibits its activity

Gene: RRM1  |  Organism: Homo sapiens  |  Synonyms: Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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