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Recombinant Human Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

Recombinant Human Ribonucleoside-diphosphate reductase subunit M2 (RRM2) — Provides the precursors necessary for DNA synthesis. Purity >90%.

SKU: BCRECP-001568 Categories: ,

Product Specifications

Product SkuBCRECP-001568
Product DescriptionRecombinant Human Ribonucleoside-diphosphate reductase subunit M2 (RRM2) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-389aa. [Accession | P31350].
Uniprot No.P31350
Gene NamesRRM2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-389aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight60.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasTranscription

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.

Biological Context

Subcellular Location: Cytoplasm; Nucleus

Product Specifications

Recombinant Human Ribonucleoside-diphosphate reductase subunit M2 (RRM2) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-389aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 60.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Protein Biology

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling

Subcellular Location

Cytoplasm; Nucleus

Subunit

Heterodimer of a large and a small subunit. Interacts (via Cy motif and when phosphorylated at Thr-33) with CCNF; the interaction occurs exclusively in G2 and early M (PubMed:22632967)

Gene: RRM2  |  Organism: Homo sapiens  |  Synonyms: Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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