Recombinant Human Serine/arginine-rich splicing factor 3 (SRSF3), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-GB1-tagged, 17.9kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Serine/arginine-rich splicing factor 3 (SRSF3), partial

Recombinant Human Serine/arginine-rich splicing factor 3 (SRSF3), partial — Splicing factor, which binds the consensus motif 5′-C[ACU][AU]C[ACU][AC]C-3′ within pre-mRNA and promotes specific exons inclusion during alternative splicing. Purity >90%.

SKU: BCRECP-001697 Category:
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Product Specifications

Product SkuBCRECP-001697
Product DescriptionRecombinant Human Serine/arginine-rich splicing factor 3 (SRSF3) Protein is expressed from E.coli with N-terminal 6xHis-GB1-tagged. It contains 1-86aa. [Accession | P84103].
Uniprot No.P84103
Gene NamesSRSF3
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-86aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-GB1-tagged
Molecular weight17.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export.

Biological Context

Subcellular Location: Nucleus; Nucleus speckle; Cytoplasm

Product Specifications

Recombinant Human Serine/arginine-rich splicing factor 3 (SRSF3), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-86aa, with N-terminal 6xHis-GB1-tagged tag, molecular weight 17.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244)

Subcellular Location

Nucleus; Nucleus speckle; Cytoplasm

Subunit

Interacts with CPSF6 (PubMed:15169763). Interacts with RBMY1A1 (PubMed:15595951). Interacts with SREK1/SFRS12 (PubMed:10757789). Interacts with NXF1 (PubMed:12667464, PubMed:17036044). Interacts with YTHDC1, leading to recruitment to RNA elements adjacent to m6A sites (PubMed:26876937, PubMed:28984244). Interacts with SRSP; increases SRSF3 binding to specific exons (PubMed:32440474)

Gene: SRSF3  |  Organism: Homo sapiens  |  Synonyms: Pre-mRNA-splicing factor SRP20; Splicing factor, arginine/serine-rich 3
Key Publications

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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