Recombinant Human Serine/threonine-protein phosphatase 2A regulatory subunit B' subunit gamma (PPP2R3C), Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 60.2kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Serine/threonine-protein phosphatase 2A regulatory subunit B’ subunit gamma (PPP2R3C)

Recombinant Human Serine/threonine-protein phosphatase 2A regulatory subunit B’ subunit gamma (PPP2R3C) — May regulate MCM3AP phosphorylation through phosphatase recruitment. Purity >90%.

SKU: BCRECP-001432 Categories: ,
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Product Specifications

Product SkuBCRECP-001432
Product DescriptionRecombinant Human Serine/threonine-protein phosphatase 2A regulatory subunit B' subunit gamma (PPP2R3C) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 1-453aa. [Accession | Q969Q6].
Uniprot No.Q969Q6
Gene NamesPPP2R3C
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-453aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight60.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.

Biological Context

Subcellular Location: Nucleus; Cytoplasm
Tissue Specificity: Ubiquitously expressed in brain and other tissues
Disease Association: Myoectodermal gonadal dysgenesis syndrome (MEGD) : An autosomal recessive disorder characterized by 46,XY complete gonadal dysgenesis and extragonadal anomalies, including typical facial gestalt, low birth weight, myopathy, rod and cone dystrophy, anal atresia, omphalocele, sensorineural hearing loss, dry and scaly skin, skeletal abnormalities, renal agenesis and neuromotor delay. [The disease is caused by variants affecting the gene represented in this entry] | Spermatogenic failure 36 (SPGF36) : An autosomal dominant infertility disorder due to teratozoospermia, with spermatozoa showing anomalies of the head, acrosome, and nucleus. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Serine/threonine-protein phosphatase 2A regulatory subunit B' subunit gamma (PPP2R3C) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-453aa, with C-terminal 6xHis-tagged tag, molecular weight 60.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

May regulate MCM3AP phosphorylation through phosphatase recruitment (By similarity). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex (PubMed:24333728). May play a role in the activation-induced cell death of B-cells (By similarity)

Subcellular Location

Nucleus; Cytoplasm

Disease Association

Myoectodermal gonadal dysgenesis syndrome (MEGD) : An autosomal recessive disorder characterized by 46,XY complete gonadal dysgenesis and extragonadal anomalies, including typical facial gestalt, low birth weight, myopathy, rod and cone dystrophy, anal atresia, omphalocele, sensorineural hearing loss, dry and scaly skin, skeletal abnormalities, renal agenesis and neuromotor delay. [The disease is caused by variants affecting the gene represented in this entry] | Spermatogenic failure 36 (SPGF36) : An autosomal dominant infertility disorder due to teratozoospermia, with spermatozoa showing anomalies of the head, acrosome, and nucleus. [The disease may be caused by variants affecting the gene represented in this entry]

Tissue Specificity

Ubiquitously expressed in brain and other tissues

Subunit

Interacts with MCM3AP/GANP. Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1

Gene: PPP2R3C  |  Organism: Homo sapiens  |  Synonyms: Protein phosphatase subunit G5PR; Rhabdomyosarcoma antigen MU-RMS-40.6A/6C
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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