Recombinant Human Serotonin N-acetyltransferase (AANAT), Homo sapiens (Human), E.coli, N-terminal 10xHis-GST-tagged, 51.8kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Serotonin N-acetyltransferase (AANAT)

Recombinant Human Serotonin N-acetyltransferase (AANAT) — Controls the night/day rhythm of melatonin production in the pineal gland. Purity >85%.

SKU: BCRECP-000001 Categories: ,
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Product Specifications

Product SkuBCRECP-000001
Product DescriptionRecombinant Human Serotonin N-acetyltransferase (AANAT) Protein is expressed from E.coli with N-terminal 10xHis-GST-tagged. It contains 1-207aa. [Accession | Q16613].
Uniprot No.Q16613
Gene NamesAANAT
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-207aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-GST-tagged
Molecular weight51.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland
Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2

Product Specifications

Recombinant Human Serotonin N-acetyltransferase (AANAT) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-207aa, with N-terminal 10xHis-GST-tagged tag, molecular weight 51.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin

Subcellular Location

Cytoplasm

Tissue Specificity

Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland

Subunit

Monomer (By similarity). Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-31. Phosphorylation on Ser-205 also allows binding to YWHAZ, but with lower affinity. The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation (By similarity). It may also prevent thiol-dependent inactivation (By similarity)

Pathway

Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2

Gene: AANAT  |  Organism: Homo sapiens  |  Synonyms: Aralkylamine N-acetyltransferase
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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