Recombinant Human Serotransferrin(TF) (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 104.1kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Serotransferrin(TF) (Active)

Recombinant Human Serotransferrin(TF) (Active) — (Microbial infection) Serves as an iron source for parasite T. Purity >95%.

SKU: BCACP-000260 Category:
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Product SKUBCACP-000260
Product DescriptionRecombinant Human Serotransferrin(TF) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 20-698aa. [Accession | P02787].
Uniprot No.P02787
Gene NamesTF
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region20-698aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight104.1kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Cynomolgus CLEC4C at 2 μg/mL can bind Anti-CLEC4C recombinant antibody. The EC50 is 5.506-6.472 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesTransferrin;Beta-1 metal-binding globulin;Siderophilin;TF ;PRO1400

Function

(Microbial infection) Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed by the liver and secreted in plasma
Disease Association: Atransferrinemia (ATRAF) : A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Serotransferrin(TF) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 20-698aa, with C-terminal hFc1-tagged tag, molecular weight 104.1kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus CLEC4C at 2 μg/mL can bind Anti-CLEC4C recombinant antibody. The EC50 is 5.506-6.472 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

(Microbial infection) Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use

Subcellular Location

Secreted

Disease Association

Atransferrinemia (ATRAF) : A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed by the liver and secreted in plasma

Subunit

(Microbial infection) Binds to Neisseria transferrin-binding protein B (tbpb or tbp2)

Gene: TF  |  Organism: Homo sapiens  |  Synonyms: Beta-1 metal-binding globulin; Siderophilin

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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