Recombinant Human Serum amyloid P-component (APCS) (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 24.6 kDa, purity >95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.

Recombinant Human Serum amyloid P-component (APCS) (Active)

Recombinant Human Serum amyloid P-component (APCS) (Active) — Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Purity >95%.

SKU: BCACP-000607 Category:
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Product SKUBCACP-000607
Product DescriptionRecombinant Human Serum amyloid P-component (APCS) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 20-223aa. [Accession | P02743].
Uniprot No.P02743
Gene NamesAPCS
PurityGreater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region20-223aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight24.6 kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Human IL18RAP at 2 μg/mL can bind anti-IL18RAP recombinant antibody.The EC50 is 0.7969-0.9304 ng/mL.;IL18RAP Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human IL18RAP with an affinity constant of 0.267 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesSerum amyloid P-component; SAP; 9.5S alpha-1-glycoprotein [Cleaved into: Serum amyloid P-component(1-203]

Function

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Found in serum and urine
Disease Association: [SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits]

Product Specifications

Recombinant Human Serum amyloid P-component (APCS) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 20-223aa, with C-terminal 10xHis-tagged tag, molecular weight 24.6 kDa, purity Greater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin

Subcellular Location

Secreted

Disease Association

[SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits]

Tissue Specificity

Found in serum and urine

Subunit

Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits

Gene: APCS  |  Organism: Homo sapiens  |  Synonyms: 9.5S alpha-1-glycoprotein
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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