Recombinant Human Serum amyloid P-component (APCS) (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 24.6 kDa, purity >95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.

Recombinant Human Serum amyloid P-component (APCS) (Active)

Recombinant Human Serum amyloid P-component (APCS) (Active) — Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Purity >95%.

SKU: BCACP-000607 Category:
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Product SKUBCACP-000607
Product DescriptionRecombinant Human Serum amyloid P-component (APCS) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 20-223aa. [Accession | P02743].
Uniprot No.P02743
Gene NamesAPCS
PurityGreater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region20-223aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight24.6 kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Human IL18RAP at 2 μg/mL can bind anti-IL18RAP recombinant antibody.The EC50 is 0.7969-0.9304 ng/mL.;IL18RAP Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human IL18RAP with an affinity constant of 0.267 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesSerum amyloid P-component; SAP; 9.5S alpha-1-glycoprotein [Cleaved into: Serum amyloid P-component(1-203]

Function

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Found in serum and urine
Disease Association: [SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits]

Product Specifications

Recombinant Human Serum amyloid P-component (APCS) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 20-223aa, with C-terminal 10xHis-tagged tag, molecular weight 24.6 kDa, purity Greater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA.Immobilized Human IL18RAP at 2 μg/mL can bind anti-IL18RAP recombinant antibody.The EC50 is 0.7969-0.9304 ng/mL.;IL18RAP Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human IL18RAP with an affinity constant of 0.267 nM as detected by MetaSPR Assay (WeSPRTM 200).

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin

Subcellular Location

Secreted

Disease Association

[SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits]

Tissue Specificity

Found in serum and urine

Subunit

Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits

Gene: APCS  |  Organism: Homo sapiens  |  Synonyms: 9.5S alpha-1-glycoprotein
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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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