Recombinant Human Signal peptidase complex catalytic subunit SEC11C (SEC11C), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 32.2kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Signal peptidase complex catalytic subunit SEC11C (SEC11C), partial

Recombinant Human Signal peptidase complex catalytic subunit SEC11C (SEC11C), partial — Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmi… Purity >…

SKU: BCRECP-001597 Categories: , ,
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Product Specifications

Product SkuBCRECP-001597
Product DescriptionRecombinant Human Signal peptidase complex catalytic subunit SEC11C (SEC11C) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 49-192aa. [Accession | Q9BY50].
Uniprot No.Q9BY50
Gene NamesSEC11C
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region49-192aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight32.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.

Biological Context

Subcellular Location: Endoplasmic reticulum membrane (Single-pass type II membrane protein)

Product Specifications

Recombinant Human Signal peptidase complex catalytic subunit SEC11C (SEC11C), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 49-192aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 32.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (PubMed:34388369)

Subcellular Location

Endoplasmic reticulum membrane (Single-pass type II membrane protein)

Subunit

Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:34388369). Within the complex, interacts with SPCS2 and SPCS3 (PubMed:34388369). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (PubMed:34388369). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (PubMed:34388369)

Gene: SEC11C  |  Organism: Homo sapiens  |  Synonyms: Microsomal signal peptidase 21 kDa subunit; SEC11 homolog C; SEC11-like protein 3; SPC21

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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