Recombinant Human Signal recognition particle subunit SRP72 (SRP72)

Function

Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:21073748, PubMed:27899666). Can bind 7SL RNA with low affinity (PubMed:21073748, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity)

Subcellular Location

Cytoplasm; Endoplasmic reticulum

Disease Association

Bone marrow failure syndrome 1 (BMFS1) : An autosomal dominant disease characterized by aplastic anemia and myelodysplasia resulting from bone marrow failure. Aplastic anemia is a form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. Myelodysplasia is a clonal hematopoietic stem cell disorder in which immature cells in the bone marrow become malformed and dysfunctional. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Heterodimer with SRP68 (PubMed:16672232, PubMed:27899666, PubMed:28369529). SRP68-SRP72 heterodimer formation is stabilized by the presence of 7SL RNA (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). Within the SRP complex, interacts (via N-terminus) with SRP68 (via C-terminus) (PubMed:16672232, PubMed:27899666, PubMed:28369529)

• Gowda K. et al. Protein SRP72 sequence of human signal recognition particle. (JUL-)
• Utz P.J. et al. Sequence of human signal recognition particle (SRP) 72. (JUN-)
• Bechtel S. et al. The full-ORF clone resource of the German cDNA consortium. — BMC Genomics (2007)
• Hillier L.W. et al. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. — Nature (2005)
• Mural R.J. et al. PubMed: CI-56FT96O07V0QG (JUL-)
• Bienvenut W.V. et al. PubMed: CI-F514K8AQPFKCP (MAR-)
• Iakhiaeva E. et al. Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains. — Protein Sci. (2006)
• Daub H. et al. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. — Mol. Cell (2008)