Recombinant Human Single Ig IL-1-related receptor(SIGIRR), partial, Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 14.6kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Single Ig IL-1-related receptor(SIGIRR), partial

Recombinant Human Single Ig IL-1-related receptor(SIGIRR), partial — Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Purity >95%.

SKU: BCRECP-001632 Categories: ,
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Product Specifications

Product SkuBCRECP-001632
Product DescriptionRecombinant Human Single Ig IL-1-related receptor(SIGIRR) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 1-118aa. [Accession | Q6IA17].
Uniprot No.Q6IA17
Gene NamesSIGIRR
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-118aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight14.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Biological Context

Subcellular Location: Membrane (Single-pass type III membrane protein)
Tissue Specificity: Mainly expressed in epithelial tissues such as kidney, lung and gut

Product Specifications

Recombinant Human Single Ig IL-1-related receptor(SIGIRR), partial is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-118aa, with N-terminal 6xHis-tagged tag, molecular weight 14.6kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP

Subcellular Location

Membrane (Single-pass type III membrane protein)

Tissue Specificity

Mainly expressed in epithelial tissues such as kidney, lung and gut

Subunit

Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3

Gene: SIGIRR  |  Organism: Homo sapiens  |  Synonyms: Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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