Function
Binds to acetylated and methylated histones, including H3K4me3 and H4K20me3, probably acting as a histone reader that recognizes chromatin marks and mediates downstream cellular effects. Promotes canonical WNT signaling, and is involved in the down-regulation of cell proliferation.
Biological Context
Subcellular Location: Cytoplasm; Nucleus
Disease Association: Lui-Jee-Baron syndrome (LJBS) : An X-linked disorder characterized by prenatal onset, generalized overgrowth, extreme tall stature, enlarged liver and spleen, macrocephaly, dysmorphic features, and normal development. Hemizygous males are more severely affected than heterozygous females. [The disease may be caused by variants affecting the gene represented in this entry. A variant causing frameshift and truncation of the SPIN4 protein has been found in one family with Lui-Jee-Baron syndrome. In mice, SPIN4 truncating mutations result in features recapitulating the human disease, including generalized overgrowth and increased longitudinal bone growth. Growth plate analysis of mutant mice reveales increased cell proliferation in the proliferative zone and an increased number of progenitor chondrocytes in the resting zone]
Product Specifications
Recombinant Human Spindlin-4 (SPIN4), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 36-249aa, with N-terminal 6xHis-tagged tag, molecular weight 28.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
