Function
Functions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A.
Biological Context
Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris
Disease Association: Microphthalmia, syndromic, 9 (MCOPS9) : A rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. [The disease is caused by variants affecting the gene represented in this entry] | [Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe]
Product Specifications
Recombinant Human Stimulated by retinoic acid gene 6 protein homolog (STRA6), partial is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-50aa, with C-terminal hFc1-tagged tag, molecular weight 33.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
