Recombinant Human Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1), partial, Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 39.5kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1), partial

Recombinant Human Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1), partial — Required for morphological development, cell alignment and migration of lymphatic endothelial cells during embryonic development, potentially via modulation of ANGPT2-TIE1 signa…

SKU: BCRECP-001720 Categories: ,
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Product Specifications

Product SkuBCRECP-001720
Product DescriptionRecombinant Human Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1) Protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 736-827aa. [Accession | Q4LDE5].
Uniprot No.Q4LDE5
Gene NamesSVEP1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region736-827aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight39.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Required for morphological development, cell alignment and migration of lymphatic endothelial cells during embryonic development, potentially via modulation of ANGPT2-TIE1 signaling and subsequent activation of FOXC2 transcription. Required for embryonic lymphatic vascular development, via mediating the correct formation of the first lymphovenous contact site and tight association of the lymphatic endothelium with the venous endothelium. Represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells, via its interaction with integrins, thereby inhibiting vasocontraction.

Biological Context

Subcellular Location: Secreted; Nucleus; Cytoplasm; Membrane (Peripheral membrane protein)
Tissue Specificity: Expressed in mesenchymal cells (at protein level). Expressed in vascular smooth muscle cells (at protein level). Expressed throughout the epidermis, expression is most prominent in the basal and lower suprabasal layers of the epidermis and in dermal fibroblasts in the upper dermis (at protein level). Abundantly expressed in the placenta, weakly expressed in heart and skeletal muscle. Also expressed in the lung, adrenal gland and cerebellum

Product Specifications

Recombinant Human Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1), partial is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 736-827aa, with C-terminal hFc1-tagged tag, molecular weight 39.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Required for morphological development, cell alignment and migration of lymphatic endothelial cells during embryonic development, potentially via modulation of ANGPT2-TIE1 signaling and subsequent activation of FOXC2 transcription (By similarity). Required for embryonic lymphatic vascular development, via mediating the correct formation of the first lymphovenous contact site and tight association of the lymphatic endothelium with the venous endothelium (By similarity). Represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells, via its interaction with integrins, thereby inhibiting vasocontraction (PubMed:35802072). Promotes platelet activation, via its interaction with PEAR1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). Plays a role in epidermal development and keratinocyte differentiation, independent of cell-cell adhesion (PubMed:27892606). May play a role in initial cell attachment of stromal osteogenic cells (By similarity). May promote myoblast cell adhesion when in the presence of integrin ITGA9:ITGB1 (By similarity)

Subcellular Location

Secreted; Nucleus; Cytoplasm; Membrane (Peripheral membrane protein)

Tissue Specificity

Expressed in mesenchymal cells (at protein level) (PubMed:16206243). Expressed in vascular smooth muscle cells (at protein level) (PubMed:35802072). Expressed throughout the epidermis, expression is most prominent in the basal and lower suprabasal layers of the epidermis and in dermal fibroblasts in the upper dermis (at protein level) (PubMed:27892606). Abundantly expressed in the placenta, weakly expressed in heart and skeletal muscle (PubMed:11062057, PubMed:27892606). Also expressed in the lung, adrenal gland and cerebellum (PubMed:27892606)

Subunit

Interacts (via Sushi domain 21) with ITGA9:ITGB1; thereby inhibits Ca(2+) intracellular signaling and as a result represses vasocontraction (PubMed:35802072). Interacts (via Sushi domain 21) with ITGA4:ITGB1; thereby inhibits Ca(2+) intracellular signaling and as a result represses vasocontraction (PubMed:35802072). Interacts with ANGPT1 and ANGPT2 (By similarity). Interacts with PEAR1 (via extracellular domain) (PubMed:36792666). Interacts with HSPG2, TLN1, FN1, COPA, CCT2, IQGAP1, LAMC1 and NID1 (By similarity). Interacts (via C-terminus) with TIE1 (PubMed:37097004)

Gene: SVEP1  |  Organism: Homo sapiens  |  Synonyms: CCP module-containing protein 22; Polydom; Selectin-like osteoblast-derived protein; Serologically defined breast cancer antigen NY-BR-38
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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