Recombinant Human Syntaxin-17 (STX17) Protein

Function

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion (PubMed:23217709, PubMed:25686604, PubMed:28306502). STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604, PubMed:28306502, PubMed:28504273). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355)

Subcellular Location

Endoplasmic reticulum membrane (Multi-pass membrane protein); Smooth endoplasmic reticulum membrane (Multi-pass membrane protein); Endoplasmic reticulum-Golgi intermediate compartment membrane (Multi-pass membrane protein); Cytoplasmic vesicle, autophagosome membrane (Multi-pass membrane protein); Cytoplasmic vesicle, COPII-coated vesicle membrane (Multi-pass membrane protein); Cytoplasm, cytosol; Mitochondrion membrane (Multi-pass membrane protein); Autolysosome membrane (Multi-pass membrane protein)

Subunit

(Microbial infection) The interactions with VAMP8, SNAP29 and VPS41 are decreased in presence of SARS coronavirus-2/SARS-CoV-2 ORF3A protein

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