Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 16.5 kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial (Active)

Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial (Active) — recombinant protein from Homo sapiens (Human), expressed in Mammalian cell. Purity >90%.

SKU: BCACP-000612 Categories: ,
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Product SKUBCACP-000612
Product DescriptionRecombinant Human T-cell-specific surface glycoprotein CD28 (CD28) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 19-152aa. [Accession | P10747].
Uniprot No.P10747
Gene NamesCD28
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region19-152aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight16.5 kDa
ActivityMeasured by its ability to cleave the fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2.The specific activity is >2000 pmol/min/µg.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesT-cell-specific surface glycoprotein CD28; TP44; CD antigen CD28

Function

Enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.

Biological Context

Subcellular Location: Cell surface
Tissue Specificity: Expressed in T-cells and plasma cells, but not in less mature B-cells
Disease Association: Immunodeficiency 123 with HPV-related verrucosis (IMD123) : An autosomal recessive immunologic disorder characterized by susceptibility to human papilloma virus (HPV) infections and the development of HPV-related common verrucosis in the first decade of life. In some patients with HPV2 infection, warts may progress to severe generalized hyperkeratotic cutaneous papillomatosis with cutaneous horns ('tree-man' phenotype). In patients with HPV4 infection, warts remains stable and may even regress with age. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human T-cell-specific surface glycoprotein CD28 (CD28), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 19-152aa, with C-terminal 10xHis-tagged tag, molecular weight 16.5 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its ability to cleave the fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2.The specific activity is >2000 pmol/min/µg.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037)

Subcellular Location

Cell surface

Disease Association

Immunodeficiency 123 with HPV-related verrucosis (IMD123) : An autosomal recessive immunologic disorder characterized by susceptibility to human papilloma virus (HPV) infections and the development of HPV-related common verrucosis in the first decade of life. In some patients with HPV2 infection, warts may progress to severe generalized hyperkeratotic cutaneous papillomatosis with cutaneous horns ('tree-man' phenotype). In patients with HPV4 infection, warts remains stable and may even regress with age. [The disease may be caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in T-cells and plasma cells, but not in less mature B-cells

Subunit

Interacts with CD40LG

Gene: CD28  |  Organism: Homo sapiens  |  Synonyms: TP44
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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