Recombinant Human Tartrate-resistant acid phosphatase type 5 (ACP5), Homo sapiens (Human), Yeast, C-terminal 6xHis-tagged, 35.8kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Tartrate-resistant acid phosphatase type 5 (ACP5)

Recombinant Human Tartrate-resistant acid phosphatase type 5 (ACP5) — Involved in osteopontin/bone sialoprotein dephosphorylation. Purity >95%.

SKU: BCRECP-000022 Categories: ,
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Product Specifications

Product SkuBCRECP-000022
Product DescriptionRecombinant Human Tartrate-resistant acid phosphatase type 5 (ACP5) Protein is expressed from Yeast with C-terminal 6xHis-tagged. It contains 22-325aa. [Accession | P13686].
Uniprot No.P13686
Gene NamesACP5
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region22-325aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight35.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasMetabolism

Function

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

Biological Context

Subcellular Location: Lysosome
Disease Association: Spondyloenchondrodysplasia with immune dysregulation (SPENCDI) : A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. [The disease is caused by variants affecting the gene represented in this entry. ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease]

Product Specifications

Recombinant Human Tartrate-resistant acid phosphatase type 5 (ACP5) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 22-325aa, with C-terminal 6xHis-tagged tag, molecular weight 35.8kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias

Subcellular Location

Lysosome

Disease Association

Spondyloenchondrodysplasia with immune dysregulation (SPENCDI) : A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. [The disease is caused by variants affecting the gene represented in this entry. ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease]

Subunit

Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s)

Gene: ACP5  |  Organism: Homo sapiens  |  Synonyms: Tartrate-resistant acid ATPase; Type 5 acid phosphatase
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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