Recombinant Human Telomerase protein component 1 (TEP1), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 28.8kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Telomerase protein component 1 (TEP1), partial

Recombinant Human Telomerase protein component 1 (TEP1), partial — Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Purity >90%.

SKU: BCRECP-001756 Category:
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Product Specifications

Product SkuBCRECP-001756
Product DescriptionRecombinant Human Telomerase protein component 1 (TEP1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 2-226aa. [Accession | Q99973].
Uniprot No.Q99973
Gene NamesTEP1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-226aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight28.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle.

Biological Context

Subcellular Location: Nucleus; Chromosome, telomere
Tissue Specificity: Ubiquitous

Product Specifications

Recombinant Human Telomerase protein component 1 (TEP1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-226aa, with N-terminal 6xHis-tagged tag, molecular weight 28.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (PubMed:19179534). Component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity)

Subcellular Location

Nucleus; Chromosome, telomere

Tissue Specificity

Ubiquitous

Subunit

Associates with MVP to form part of the vault particle (By similarity). The vault is a massive cage-like structure; it consists of a dimer of half-vaults, with each half-vault comprising 39 identical MVP subunits (By similarity). The two half-vaults assemble to form the complete vault, where minor vault components such as PARP4, TEP1 and vault RNAs (vRNAs) may bind to the interior (By similarity). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs (By similarity)

Gene: TEP1  |  Organism: Homo sapiens  |  Synonyms: Telomerase-associated protein 1; p240; p80 telomerase homolog
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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