Recombinant Human Tenascin (TNC), partial

Function

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327)

Subcellular Location

Secreted, extracellular space, extracellular matrix

Disease Association

Deafness, autosomal dominant, 56 (DFNA56) : A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with postlingual onset. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Detected in fibroblasts (at protein level)

Subunit

Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 (PubMed:8824254). Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1 (PubMed:22654117)

• Nies D.E. et al. The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats. — J. Biol. Chem. (1991)
• Siri A. et al. Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies. — Nucleic Acids Res. (1991)
• Gulcher J.R. et al. Structure of the human hexabrachion (tenascin) gene. — Proc. Natl. Acad. Sci. U.S.A. (1991)
• Gherzi R. et al. Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences. — J. Biol. Chem. (1995)
• Humphray S.J. et al. DNA sequence and analysis of human chromosome 9. — Nature (2004)
• Glumoff V. et al. Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes. — Biochim. Biophys. Acta (1994)
• Gulcher J.R. et al. An alternatively spliced region of the human hexabrachion contains a repeat of potential N-glycosylation sites. — Proc. Natl. Acad. Sci. U.S.A. (1989)
• Burg M.A. et al. Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules. — J. Biol. Chem. (1996)