Recombinant Human Thrombopoietin (THPO) (Active) — Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. Purity >90%.
| Product SKU | BCACP-000404 |
| Product Description | Recombinant Human Thrombopoietin (THPO) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 22-353aa. [Accession | P40225]. |
| Uniprot No. | P40225 |
| Gene Names | THPO |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Expression System | Mammalian cell |
| Expression Region | 22-353aa |
| Species | Homo sapiens (Human) |
| Tag Info | C-terminal 10xHis-tagged |
| Molecular weight | 36.8 kDa |
| Activity | Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ITPRIPL1 at 2 μg/mL can bind Anti-ITPRIPL1 recombinant antibody . The EC50 is 3.759-4.428 ng/mL. |
| Buffer | Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0 |
| Storage | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| Alternative Names | Thrombopoietin; C-mpl ligand (ML); Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor (MGDF); Myeloproliferative leukemia virus oncogene ligand; THPO; MGDF |
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development.
Recombinant Human Thrombopoietin (THPO) (Active) — Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. Purity >90%. Suitable for ELISA and Western Blot applications.
Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.
Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ITPRIPL1 at 2 μg/mL can bind Anti-ITPRIPL1 recombinant antibody . The EC50 is 3.759-4.428 ng/mL.
Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets
Secreted
Thrombocythemia 1 (THCYT1) : A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. [The disease is caused by variants affecting the gene represented in this entry] | Amegakaryocytic thrombocytopenia, congenital, 2 (CAMT2) : A form of congenital amegakaryocytic thrombocytopenia, a hematologic disorder characterized by severe reduction of megakaryocytes and platelets at birth, and evolving into generalized bone marrow aplasia during childhood. CAMT2 is an autosomal recessive form. Most patients present with thrombocytopenia that progresses to pancytopenia. [The disease is caused by variants affecting the gene represented in this entry] | Thrombocytopenia 9 (THC9) : A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC9 is an autosomal dominant form characterized by low platelet counts in the absence of significant bleeding tendency. Some individuals may have mild mucocutaneous bleeding, whereas others may be asymptomatic. [The disease is caused by variants affecting the gene represented in this entry]
Interacts with MPL/TPOR (PubMed:37633268)
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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.
Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.
Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.
