Recombinant Human Thymidylate kinase (DTYMK), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 50.7kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Thymidylate kinase (DTYMK)

Recombinant Human Thymidylate kinase (DTYMK) — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-000546 Categories: , ,
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Product Specifications

Product SkuBCRECP-000546
Product DescriptionRecombinant Human Thymidylate kinase (DTYMK) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-212aa. [Accession | P23919].
Uniprot No.P23919
Gene NamesDTYMK
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-212aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight50.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+).

Biological Context

Disease Association: Neurodegeneration, childhood-onset, with progressive microcephaly (CONPM) : An autosomal recessive disorder characterized by global developmental delay apparent from infancy. Most severely affected individuals have severe and progressive microcephaly, early-onset seizures, lack of visual tracking, and almost no developmental milestones, resulting in early death. Less severely affected individuals have a small head circumference and severely impaired intellectual development with poor speech and motor delay. Additional features may include poor overall growth, axial hypotonia, limb hypertonia with spasticity, undescended testes, and cerebral atrophy with neuronal loss. [The disease is caused by variants affecting the gene represented in this entry]
Pathway: Pyrimidine metabolism; dTTP biosynthesis

Product Specifications

Recombinant Human Thymidylate kinase (DTYMK) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-212aa, with N-terminal GST-tagged tag, molecular weight 50.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+)

Disease Association

Neurodegeneration, childhood-onset, with progressive microcephaly (CONPM) : An autosomal recessive disorder characterized by global developmental delay apparent from infancy. Most severely affected individuals have severe and progressive microcephaly, early-onset seizures, lack of visual tracking, and almost no developmental milestones, resulting in early death. Less severely affected individuals have a small head circumference and severely impaired intellectual development with poor speech and motor delay. Additional features may include poor overall growth, axial hypotonia, limb hypertonia with spasticity, undescended testes, and cerebral atrophy with neuronal loss. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Homodimer

Pathway

Pyrimidine metabolism; dTTP biosynthesis

Gene: DTYMK  |  Organism: Homo sapiens  |  Synonyms: dTMP kinase
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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