Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged(This tag can be tested only under denaturing conditions), 86.0 kDa, purity >90% as determined by SEC-HPLC.
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Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active)

Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active) — Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Purity >90%.

SKU: BCACP-000352 Categories: ,
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Product SKUBCACP-000352
Product DescriptionRecombinant Human Thyrotropin receptor (TSHR)-VLPs protein is expressed from Mammalian cell with C-terminal 10xHis-tagged(This tag can be tested only under denaturing conditions). It contains 21-764aa. [Accession | P16473].
Uniprot No.P16473
Gene NamesTSHR
PurityGreater than 90% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region21-764aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged(This tag can be tested only under denaturing conditions)
Molecular weight86.0 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human ENPP3 at 2 μg/mL can bind Anti-ENPP3 recombinant antibody , the EC50 is 0.5355-1.248 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesThyrotropin receptor; Thyroid-stimulating hormone receptor (TSH-R)

Function

Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase.

Product Specifications

Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 21-764aa, with C-terminal 10xHis-tagged(This tag can be tested only under denaturing conditions) tag, molecular weight 86.0 kDa, purity Greater than 90% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ENPP3 at 2 μg/mL can bind Anti-ENPP3 recombinant antibody , the EC50 is 0.5355-1.248 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase (PubMed:11847099, PubMed:35940205, PubMed:35940204). This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS) (PubMed:27638195). Additionally, plays a central role in controlling thyroid cell metabolism (By similarity)

Gene: TSHR  |  Organism: Homo sapiens

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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