Recombinant Human TIR domain-containing adapter molecule 1 (TICAM1) Protein

Function

Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347, PubMed:35215908, PubMed:31511519). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (By similarity)

Subcellular Location

Cytoplasmic vesicle, autophagosome; Cytoplasm, cytosol; Mitochondrion

Disease Association

Encephalopathy, acute, infection-induced, 6, herpes-specific (IIAE6) : A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. [Disease susceptibility is associated with variants affecting the gene represented in this entry]

Tissue Specificity

Ubiquitously expressed but with higher levels in liver

Subunit

(Microbial infection) Interacts (via C-terminus) with coxsackievirus B3 (CVB3) protease 3C

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• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Begum N.A. et al. PRVTIRB is a differentially expressed gene. (MAR-)
• Yu W. et al. PubMed: CI-60FC46SDV7UM1 (JUN-)
• Bin L.-H. et al. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. — J. Biol. Chem. (2003)