Recombinant Human Transmembrane protease serine 3 (TMPRSS3) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 50.9kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Transmembrane protease serine 3 (TMPRSS3) Protein

Recombinant Human Transmembrane protease serine 3 (TMPRSS3) Protein — Probable serine protease that plays a role in hearing. Purity >85%.

SKU: BCRECP-00256TM Categories: , ,
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Product Specifications

Uniprot No.P57727
Gene NamesTMPRSS3
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-454aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight50.9kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro).

Biological Context

Subcellular Location: Endoplasmic reticulum membrane (Single-pass type II membrane protein)
Tissue Specificity: Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas
Disease Association: Deafness, autosomal recessive, 8 (DFNB8) : A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Transmembrane protease serine 3 (TMPRSS3) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-454aa, with N-terminal 10xHis-tagged tag, molecular weight 50.9kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not Test

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro)

Subcellular Location

Endoplasmic reticulum membrane (Single-pass type II membrane protein)

Disease Association

Deafness, autosomal recessive, 8 (DFNB8) : A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas

Gene: TMPRSS3  |  Organism: Homo sapiens  |  Synonyms: Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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