Recombinant Human Transmembrane protease serine 3 (TMPRSS3) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 50.9kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Transmembrane protease serine 3 (TMPRSS3) Protein

Recombinant Human Transmembrane protease serine 3 (TMPRSS3) Protein — Probable serine protease that plays a role in hearing. Purity >85%.

SKU: BCRECP-00256TM Categories: , ,
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Product Specifications

Uniprot No.P57727
Gene NamesTMPRSS3
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-454aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight50.9kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro).

Biological Context

Subcellular Location: Endoplasmic reticulum membrane (Single-pass type II membrane protein)
Tissue Specificity: Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas
Disease Association: Deafness, autosomal recessive, 8 (DFNB8) : A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Transmembrane protease serine 3 (TMPRSS3) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-454aa, with N-terminal 10xHis-tagged tag, molecular weight 50.9kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro)

Subcellular Location

Endoplasmic reticulum membrane (Single-pass type II membrane protein)

Disease Association

Deafness, autosomal recessive, 8 (DFNB8) : A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas

Gene: TMPRSS3  |  Organism: Homo sapiens  |  Synonyms: Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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