Recombinant Human Trimethylguanosine synthase (TGS1), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 31.6kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Trimethylguanosine synthase (TGS1), partial

Recombinant Human Trimethylguanosine synthase (TGS1), partial — Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. Purity >90%.

SKU: BCRECP-001771 Categories: ,
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Product Specifications

Product SkuBCRECP-001771
Product DescriptionRecombinant Human Trimethylguanosine synthase (TGS1) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 713-853aa. [Accession | Q96RS0].
Uniprot No.Q96RS0
Gene NamesTGS1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region713-853aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight31.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs).

Biological Context

Subcellular Location: Cytoplasm; Nucleus, Cajal body; Nucleus, nucleolus
Tissue Specificity: Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta

Product Specifications

Recombinant Human Trimethylguanosine synthase (TGS1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 713-853aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 31.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation

Subcellular Location

Cytoplasm; Nucleus, Cajal body; Nucleus, nucleolus

Tissue Specificity

Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta

Subunit

May form homooligomers. Interacts with CREBBP/CBP, EED/WAIT1, EP300/P300, NCOA6/PRIP, PPARBP/PBP and SMN

Gene: TGS1  |  Organism: Homo sapiens  |  Synonyms: CLL-associated antigen KW-2; Cap-specific guanine-N(2) methyltransferase; Hepatocellular carcinoma-associated antigen 137; Nuclear receptor coactivator 6-interacting protein; PRIP-interacting protein with methyltransferase motif
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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