Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 48.0kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) — Receptor for TNFSF5/CD40LG. Purity >95%.

SKU: BCRECP-000289 Categories: , ,
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Product Specifications

Product SkuBCRECP-000289
Product DescriptionRecombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40) Protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 21-193aa. [Accession | P25942].
Uniprot No.P25942
Gene NamesCD40
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region21-193aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight48.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: B-cells and in primary carcinomas
Disease Association: Immunodeficiency with hyper-IgM 3 (HIGM3) : A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 21-193aa, with C-terminal hFc1-tagged tag, molecular weight 48.0kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)

Subcellular Location

Secreted

Disease Association

Immunodeficiency with hyper-IgM 3 (HIGM3) : A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

B-cells and in primary carcinomas

Subunit

Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation

Gene: CD40  |  Organism: Homo sapiens  |  Synonyms: B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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