Recombinant Human Tyrosine-protein kinase receptor UFO (AXL) (D266N), partial, Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 75.1kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Tyrosine-protein kinase receptor UFO (AXL) (D266N), partial

Recombinant Human Tyrosine-protein kinase receptor UFO (AXL) (D266N), partial — (Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes. Purity >85%.

SKU: BCRECP-000145 Categories: , ,
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Product Specifications

Product SkuBCRECP-000145
Product DescriptionRecombinant Human Tyrosine-protein kinase receptor UFO (AXL) (D266N) Protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 26-451aa(D266N). [Accession | P30530].
Uniprot No.P30530
Gene NamesAXL
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region26-451aa(D266N)
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight75.1kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

(Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes. Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection. Interferon signaling inhibition occurs via an SOCS1-dependent mechanism.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue
Disease Association: [AXL and its ligand GAS6 are highly expressed in thyroid carcinoma tissues, and might thus be involved in thyroid tumorigenesis. Overexpression of AXL and its ligand was also detected in many other cancers such as myeloproliferative disorders, prostatic carcinoma cells, or breast cancer]

Product Specifications

Recombinant Human Tyrosine-protein kinase receptor UFO (AXL) (D266N), partial is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 26-451aa(D266N), with C-terminal hFc1-tagged tag, molecular weight 75.1kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

(Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210)

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Disease Association

[AXL and its ligand GAS6 are highly expressed in thyroid carcinoma tissues, and might thus be involved in thyroid tumorigenesis. Overexpression of AXL and its ligand was also detected in many other cancers such as myeloproliferative disorders, prostatic carcinoma cells, or breast cancer]

Tissue Specificity

Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue

Subunit

Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TNS2. Part of a complex including AXL, TNK2 and GRB2, in which GRB2 promotes AXL recruitment by TNK2

Gene: AXL  |  Organism: Homo sapiens  |  Synonyms: AXL oncogene
Key Publications

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

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Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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