Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), partial, Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 29.3kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), partial

Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), partial — Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene exp… Purity >…

SKU: BCRECP-001477 Categories: ,
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Product Specifications

Product SkuBCRECP-001477
Product DescriptionRecombinant Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 1-189aa. [Accession | Q15678].
Uniprot No.Q15678
Gene NamesPTPN14
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-189aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight29.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner.

Biological Context

Subcellular Location: Cytoplasm; Cytoplasm, cytoskeleton; Nucleus
Tissue Specificity: Ubiquitous
Disease Association: Choanal atresia and lymphedema (CATLPH) : A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. [The disease is caused by variants affecting the gene represented in this entry. A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family] | [Influence clinical severity of hereditary haemorragic telagiectasia (HHT)]

Product Specifications

Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-189aa, with C-terminal 6xHis-tagged tag, molecular weight 29.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor

Subcellular Location

Cytoplasm; Cytoplasm, cytoskeleton; Nucleus

Disease Association

Choanal atresia and lymphedema (CATLPH) : A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. [The disease is caused by variants affecting the gene represented in this entry. A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family] | [Influence clinical severity of hereditary haemorragic telagiectasia (HHT)]

Tissue Specificity

Ubiquitous

Subunit

Interacts with FLT4; the interaction is enhanced by stimulation with VEGFC. Interacts (via PPxY motifs) with YAP1 (via WW domains); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional co-activator activity

Gene: PTPN14  |  Organism: Homo sapiens  |  Synonyms: Protein-tyrosine phosphatase pez
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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