Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), partial, Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 29.3kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), partial

Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), partial — Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene exp… Purity >…

SKU: BCRECP-001477 Categories: ,
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Product Specifications

Product SkuBCRECP-001477
Product DescriptionRecombinant Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 1-189aa. [Accession | Q15678].
Uniprot No.Q15678
Gene NamesPTPN14
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-189aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight29.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner.

Biological Context

Subcellular Location: Cytoplasm; Cytoplasm, cytoskeleton; Nucleus
Tissue Specificity: Ubiquitous
Disease Association: Choanal atresia and lymphedema (CATLPH) : A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. [The disease is caused by variants affecting the gene represented in this entry. A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family] | [Influence clinical severity of hereditary haemorragic telagiectasia (HHT)]

Product Specifications

Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-189aa, with C-terminal 6xHis-tagged tag, molecular weight 29.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor

Subcellular Location

Cytoplasm; Cytoplasm, cytoskeleton; Nucleus

Disease Association

Choanal atresia and lymphedema (CATLPH) : A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. [The disease is caused by variants affecting the gene represented in this entry. A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family] | [Influence clinical severity of hereditary haemorragic telagiectasia (HHT)]

Tissue Specificity

Ubiquitous

Subunit

Interacts with FLT4; the interaction is enhanced by stimulation with VEGFC. Interacts (via PPxY motifs) with YAP1 (via WW domains); this interaction leads to the cytoplasmic sequestration of YAP1 and inhibits its transcriptional co-activator activity

Gene: PTPN14  |  Organism: Homo sapiens  |  Synonyms: Protein-tyrosine phosphatase pez
Key Publications

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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