Recombinant Human U1 small nuclear ribonucleoprotein A (SNRPA), partial, Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 36.9kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human U1 small nuclear ribonucleoprotein A (SNRPA), partial

Recombinant Human U1 small nuclear ribonucleoprotein A (SNRPA), partial — Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5′ splice-site and the subsequent assembly of the spliceosome. Purity >95%.

SKU: BCRECP-001674 Category:
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Product Specifications

Product SkuBCRECP-001674
Product DescriptionRecombinant Human U1 small nuclear ribonucleoprotein A (SNRPA) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 8-278aa. [Accession | P09012].
Uniprot No.P09012
Gene NamesSNRPA
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region8-278aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight36.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasTranscription

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP.

Biological Context

Subcellular Location: Nucleus

Product Specifications

Recombinant Human U1 small nuclear ribonucleoprotein A (SNRPA), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 8-278aa, with C-terminal 6xHis-tagged tag, molecular weight 36.9kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs

Subcellular Location

Nucleus

Subunit

U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component of a snRNP-free complex with SFPQ. Interacts with IVNS1ABP (via BACK domain); the interaction is indirect (PubMed:30538201)

Gene: SNRPA  |  Organism: Homo sapiens
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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