Recombinant Human UDP-glucuronosyltransferase 1A8 (UGT1A8) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 59.9kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human UDP-glucuronosyltransferase 1A8 (UGT1A8) Protein

Recombinant Human UDP-glucuronosyltransferase 1A8 (UGT1A8) Protein — recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system. Purity >85%.

SKU: BCRECP-00134TM Categories: ,
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Product Specifications

Uniprot No.Q9HAW9
Gene NamesUGT1A8
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region26-530aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight59.9kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.

Biological Context

Subcellular Location: Endoplasmic reticulum membrane (Single-pass membrane protein)
Tissue Specificity: Expressed in liver, kidney, colon and small intestine

Product Specifications

Recombinant Human UDP-glucuronosyltransferase 1A8 (UGT1A8) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 26-530aa, with N-terminal 10xHis-tagged tag, molecular weight 59.9kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1

Subcellular Location

Endoplasmic reticulum membrane (Single-pass membrane protein)

Tissue Specificity

Expressed in liver, kidney, colon and small intestine

Subunit

Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9 and UGT1A10 (PubMed:20610558)

Gene: UGT1A8  |  Organism: Homo sapiens  |  Synonyms: UDP-glucuronosyltransferase 1-8; UDP-glucuronosyltransferase 1-H
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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