Function
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Product Specifications
Recombinant Human V-set domain-containing T-cell activation inhibitor 1 (VTCN1) , partial (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 29-258aa, with C-terminal 10xHis-tagged tag, molecular weight 27.2 kDa, purity Greater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.
Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.
Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ITGAV&ITGB6 at 2 μg/mL can bind Macaca mulatta TGFB1 (M)). The EC50 is 8.899-14.82 ng/mL.;Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis ITGAV&ITGB6 at 2 μg/mL can bind Anti-ITGB6 recombinant antibody. The EC50 is 4.251-5.103 ng/mL.
Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.
