Recombinant Human Zinc finger protein GLI1 (GLI1), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 23.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Zinc finger protein GLI1 (GLI1), partial

Recombinant Human Zinc finger protein GLI1 (GLI1), partial — Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Purity >90%.

SKU: BCRECP-000754 Category:
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Product Specifications

Product SkuBCRECP-000754
Product DescriptionRecombinant Human Zinc finger protein GLI1 (GLI1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 921-1106aa. [Accession | P08151].
Uniprot No.P08151
Gene NamesGLI1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region921-1106aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight23.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasDevelopmental Biology

Function

Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1.

Biological Context

Subcellular Location: Cytoplasm; Nucleus
Tissue Specificity: Undetectable in normal cells but highly expressed in cancer cells
Disease Association: Polydactyly, postaxial, A8 (PAPA8) : A form of postaxial polydactyly, a condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal. PAPA8 is an autosomal recessive condition characterized by the presence of postaxial extra digits (hexadactyly) on the hands and/or the feet. [The disease is caused by variants affecting the gene represented in this entry] | Polydactyly, preaxial 1 (PPD1) : A form of polydactyly, a condition defined by the occurrence of supernumerary digits in the upper and/or lower extremities. Preaxial or radial polydactyly refers to the presence of extra digits on the radial side of the hand. PPD1 is an autosomal recessive form characterized by duplication of the distal phalanx of the thumb. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Zinc finger protein GLI1 (GLI1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 921-1106aa, with N-terminal 6xHis-tagged tag, molecular weight 23.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Acts as a transcriptional activator, but activates a different set of genes than isoform 1 (PubMed:19706761). Activates expression of CD24, unlike isoform 1 (PubMed:19706761)

Subcellular Location

Cytoplasm; Nucleus

Disease Association

Polydactyly, postaxial, A8 (PAPA8) : A form of postaxial polydactyly, a condition characterized by the occurrence of supernumerary digits in the upper and/or lower extremities. In postaxial polydactyly type A, the extra digit is well-formed and articulates with the fifth or a sixth metacarpal/metatarsal. PAPA8 is an autosomal recessive condition characterized by the presence of postaxial extra digits (hexadactyly) on the hands and/or the feet. [The disease is caused by variants affecting the gene represented in this entry] | Polydactyly, preaxial 1 (PPD1) : A form of polydactyly, a condition defined by the occurrence of supernumerary digits in the upper and/or lower extremities. Preaxial or radial polydactyly refers to the presence of extra digits on the radial side of the hand. PPD1 is an autosomal recessive form characterized by duplication of the distal phalanx of the thumb. [The disease may be caused by variants affecting the gene represented in this entry]

Tissue Specificity

Undetectable in normal cells but highly expressed in cancer cells

Subunit

Interacts with SUFU; sequestering GLI1 in the cytoplasm (PubMed:10806483, PubMed:10559945, PubMed:24217340, PubMed:24311597, PubMed:28965847). Interacts with KIF7 (By similarity). Interacts with STK36 (PubMed:10806483). Interacts with ZIC1; the interaction enhances transcription activation (PubMed:11238441)

Gene: GLI1  |  Organism: Homo sapiens  |  Synonyms: Glioma-associated oncogene; Oncogene GLI
Key Publications

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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